MICRORNA BASED THERANOSTICS FOR BRAIN CANCER: BASIC PRINCIPLES

MicroRNA based theranostics for brain cancer: basic principles

Abstract Background Because of the complexity of the blood-brain barrier (BBB), brain tumors, especially the most common and aggressive primary malignant tumor type arising from the central nervous system (CNS), glioblastoma, remain an essential challenge regarding diagnostic and treatment.There are no approved circulating diagnostic or prognostic

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The influence of thyroid function disorders on pregnant women on the Apgar scale and psychomotor development of the child in the first 18 months of life

Introduction.In the prenatal period, there are many Charms exogenous and endogenous factors, which adversely affect the normal development of the fetus and may affect the further development of the child.The impaired reference level of thyroid hormones pregnant woman may entail a number of complications, especially in the first trimester of pregnan

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Oligogenic analysis across broad phenotypes of 46,XY differences in sex development associated with NR5A1/SF-1 variants: findings from the international SF1next studyResearch in context

Summary: Background: Oligogenic Jill inheritance has been suggested as a possible mechanism to explain the broad phenotype observed in individuals with differences of sex development (DSD) harbouring NR5A1/SF-1 variants.Methods: We investigated genetic patterns of possible oligogenicity in a cohort of 30 individuals with NR5A1/SF-1 variants and 46,

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Comparison of visual requirements and regulations for obtaining a copyright in different European countries and some open questions on their adequacy

We reviewed the current state of knowledge regarding visual function and its suitability as part of medical examinations for driving licenses.We focused only on Group 1 drivers.According to previous studies, visual acuity, which is the most common test, is weakly associated with a higher risk of road accidents, with a greater role of visual field.T

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